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Summer 2018 Undergraduate Research Fellowship students reflect on summer experiences

SCRM-SURF 2018 Students: ??, Jenny Jang, ??, Grace Zhang, and Jacob Kalathoor (Reina Koran not pictured)

From studying how to get iPS cells to beat like a heart to stimulating retinal regeneration in zebrafish, six outstanding Notre Dame undergraduate students participated in a summer’s worth of research thanks to the Center for Stem Cells and Regenerative Medicine’s Summer Undergraduate Research Fellowship (SURF): Stephen Landy, Jenny Jang, Seth Tautges, Grace Zhang, Jacob Kalathoor, and Reina Koran (not pictured).

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SCReM 2018 Travel Fellowship recipient, Kimberly Curtis, presents at World Congress of Biomechanics

Screm 2018Kimberly Curtis at World Congress of Biomechanics in Dublin, Ireland

In describing her work, SCReM 2018 Travel Fellowship recipient, Kimberly Curtis, finds that daily activities, such as walking or running, help bone to maintain a strong and healthy architecture due to its ability to adapt to mechanical loading. Osteocytes are resident cells embedded within the mineralized bone matrix and are able to sense mechanical stimulation and elicit a cellular response to increase bone mass. However, there are various cell types in the bone marrow, some of which are mechanosensitive and contribute to bone formation. In her tissue mechanics lab, they culture cylindrical trabecular bone explants harvested from porcine vertebrae in a custom bioreactor. The bioreactor enables them to mechanically stimulate the marrow independent of the osteocytes residing in the mineralized matrix. Using this system, they were able to detect a significant increase in bone formation in stimulated explants compared to unstimulated explants, indicating that marrow cells are mechanosensitive. They also measured an increase in mechanoregulatory cFos gene expression in stimulated marrow cells.…

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Carter Snead elected as Hastings Center Fellow

The Hastings Center draws its Fellows from across the disciplines and hails them as “an elected group of individuals of outstanding accomplishment, whose work has informed scholarship and/or public understanding of complex ethical issues in health, health care, life sciences research and the environment.”

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