Jeremiah Zartman
Assistant Professor, Department of Chemical and Biomolecular Engineering, College of Engineering
Phone: 574-631-0455
Office: 122C Cushing Hall
Identifying the control systems for tissue repair is important for understanding the underlying causes of birth defects. The formation of an embryo is an extraordinarily robust process, exhibiting the ability to control tissue size in the face of environmental and genetic perturbations. Such size control is achieved via coordination of cell growth, proliferation, death and rearrangement, and can be divided into two steps: initial specification and maintenance. While much work has focused on the specification of cellular fates during early embryonic development, the mechanisms that ensure the maintenance of tissue sizes remain poorly understood.
The Zartman lab develops and applies multidisciplinary approaches to study the robust size specification and tissue repair mechanisms of epithelial tissues. Epithelia form the outside layer of organs and play both functional and protective roles. Through collaborative efforts with multiple groups, our research focuses on the following efforts: (1) the development of computational models of tissue size regulation, which couple cell mechanics with biochemical signaling; (2) the quantitative analysis of cell-cell communication and cell dynamics through live-imaging studies at the scale of whole tissues; and (3) the application of reverse-engineering methods to analyze experimental data to facilitate computational model validation and hypothesis testing. These efforts help provide a fundamental basis for discoveries that can advance both disease diagnosis and inspire new therapeutic strategies.
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Awards:
- Biomedical Engineering Society “Rising Star Award” (recognized at the BMES CMBE conference, Key Largo, January 2-6, 2018).
Recent Papers:
- Zartman, J.J. “Chapter 7 - Organ Culture Methods for the Drosophila Wing Imaginal Disc.” In Drosophila Cells in Culture (Second Edition) (ed. Echalier, G., Perrimon, N., and Mohr, S. E.), pp. 145–164. Academic Press. (2018). ISBN: 9780128094730. doi.org/10.1016/B978-0-12-809473-0.00007-5.
- Narciso C., Zartman J.J. “Reverse engineering organogenesis through feedback loops between model systems.” Current Opinion in Biotechnology, (2018), 52, 1-8. doi: 10.1016/j.copbio.2017.12.009.
- Fukushiro-Lopes, D.F., Hegel, A.D., Rao, V., Wyatt, D., Baker, A.T., Breuer, E.K., Osipo, C., Zartman, J.J., Burnette, M., Kaja, S., Kouzoukas, D., Burris, S., Jones, W.K., Gentile, S. “Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer.” Oncotarget 2017, 9(3): 3321-3337. doi: 10.18632/oncotarget.22925.
- Narciso, C.E., Contento, N.M., Storey, T.J., Hoelzle, D.J., and Zartman, J.J. “Release of applied mechanical loading stimulates intercellular calcium waves in Drosophila wing discs.” Biophysical Journal. 2017, 113: 2, 491-501. doi: 10.1016/j.bpj.2017.05.051.
- Höök, P., Brito-Robinson, T., Narciso, C., Kim, O., Goodson, R.I., Weisel, J.W., Alber, M.S., and Zartman, J.J.* “Whole blood clot optical clearing for nondestructive 3D imaging and quantitative analysis.” Biomedical Optics Express 2017, 8 (8), 3671-3686.
- Nematbakhsh, A., Sun, W., Brodskiy, P. A., Amiri, A., Narciso, C. , Xu, Z., Zartman, J.J., and Alber, M.S. “Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.” PLOS Computational Biology 2017, 13: e1005533.
- Kursawe, J., Bardenet, R., Zartman, J.J., Baker, R. E., and Fletcher, A.G. “Robust Cell Tracking in Epithelial Tissues through Identification of Maximum Common Subgraphs.” Journal of The Royal Society Interface 2016, 13(124): 20160725. doi:10.1098/rsif.2016.0725.
Press:
- Kinzer-Ursem, T. (2017). Relieving the Pressure on Tissue Development. Biophysical Journal 113, 360–361. (This paper was highlighted by Biophysical Journal as “New and Notable.")
- Optical Society of America, 07/17/2017: Researchers Look Inside Dangerous Blood Clots with Optical Clearing Technique
- AAAS, 07/17/2017: Researchers look inside dangerous blood clots with optical clearing technique
- ScienceDaily, 07/17/2017: Peering inside dangerous blood clots with optical clearing technique
- Microscopy and Analysis (Wiley) with over 46,000 subscribers and 120,000 readers worldwide, 07/19/2017: Optical clearing makes light work of clots
- Biophotonics.World, 07/20/2017: Researchers look inside dangerous blood clots with optical clearing technique
- Controlled Environments, 07/18/2017: Researchers Look Inside Dangerous Blood Clots with Optical Clearing Technique